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Home > Birth Injury Overview > Infant Brain Damage > Infant Brain Damage Causes
Last Updated: April 16, 2025

Infant Brain Damage Causes

Page Medically Reviewed and Edited by Pierrette Mimi Poinsett, M.D.
Page Medically Reviewed and Edited by Pierrette Mimi Poinsett, M.D.

This article has been fact checked by a Board Certified Pediatrician. Sources of information for the article are listed at the bottom.

For any content issues please Contact Us.

Infant brain damage affects approximately three in every 1,000 babies born in the U.S. that come to full term[1]. Infant brain damage can be caused by oxygen deprivation during delivery, maternal infections, traumatic birth injuries, and untreated jaundice. Negligence and medical malpractice can also cause brain damage in newborns.

What Causes Infant Brain Damage?

There are several potential causes of brain damage, from maternal illness to complications of childbirth. The most common underlying cause of infant brain damage is a lack of oxygen to the baby’s brain.

Asphyxia/Hypoxic Ischemic Encephalopathy

About half of all cases of infant brain damage are caused by asphyxia, which is oxygen deprivation, during labor and delivery. Being born premature puts infants at an increased risk of asphyxia during birth.

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Hypoxic ischemic encephalopathy (HIE) is the specific type of brain injury caused by birth asphyxia in infants.

Oxygen is crucial for brain functioning, and babies cannot go long without oxygen before experiencing the lasting effects of brain damage.

Several factors can cause asphyxia. Complications with the umbilical cord may cut off blood supply to the baby, for instance, or may actually strangle the baby, cutting off oxygen. The placenta may separate early, which also cuts off oxygen to the baby.

Infections in the baby or mother, anemia, high or low blood pressure, and a blocked or malformed airway may all contribute to asphyxia in an infant.

Traumatic Birth Injuries

Traumatic birth injuries can also cause brain damage, either because they lead to asphyxia or because these types of injuries cause actual, physical damage to the skull and brain.

For instance, a doctor or midwife may pull too hard on a baby as it comes out of the birth canal, which can cause damage to the head. If the baby is stuck in the birth canal, this pulling may also result in asphyxiation.

Birth instruments may be misused or used with too much force and cause traumatic injury to the head and brain, resulting in brain damage. Forceps applied to an infant’s head can cause damage, as can using a vacuum extractor.

Any complications or difficulties during long labor can lead to brain damage in the infant. Doctors can typically prevent this by performing a Cesarean section. If they delay the procedure, brain damage may result.

Preeclampsia

If the mother develops a condition called preeclampsia, it can lead to brain damage in the infant. Preeclampsia is characterized by high blood pressure and high protein levels in the mother’s urine.[2]

This condition needs to be diagnosed and carefully treated to prevent it from becoming eclampsia and causing complications in the infant. Complications from preeclampsia have even been known to cause infant death. It may cause the death of the mother as well.

Doctors must test for preeclampsia regularly because not all women experience symptoms. Possible symptoms include weight gain, headaches, vision changes, and swelling in the face and hands.

Maternal Infections

Other conditions in the mother, particularly infections, can also lead to brain damage in an infant. Urinary tract infections and bladder infections, influenza, pneumonia, rubella, syphilis, and herpes are examples of infections that can impact the infant.

Intrauterine infections like herpes are most likely to put an infant at risk for brain damage. Because of the possible serious complications, mothers must be screened for infections and treated immediately if any are diagnosed.

Jaundice

Jaundice is a condition caused by a buildup of bilirubin in the blood. While a baby is in the womb, the mother’s liver controls bilirubin levels, and once the baby is born, its liver takes over this duty.

A baby’s liver is not well developed. Bilirubin may build up and cause yellowing of the skin and eyes, signs of jaundice.

When jaundice is severe or goes untreated, it can lead to a condition called kernicterus, a type of infant brain damage.[3]

The results may be cerebral palsy, hearing and vision problems, and later cognitive impairments. Newborns must be screened for jaundice to be treated before developing into this kind of brain damage that may not be reversible.

Infant brain damage causes are varied, and they are mostly preventable. If you are pregnant, be sure you understand the potential causes of brain damage and know of ways to prevent it.

How Is Infant Brain Damage Treated?

The symptoms that an infant has suffered brain damage during birth are not always obvious. A newborn may have certain head and facial features that indicate possible brain damage. These include a misshapen head, a prominent forehead, or unusual facial features.

Abnormal eye movements, seizures, difficulty sleeping, unusual fussiness or irritability, and excessive and unusual amounts of crying are also possible signs of brain damage.

Sometimes, the signs are not apparent until a child shows signs of developmental delays, behavior problems, or cognitive impairments.[1]

If doctors or nurses identify brain damage right away, immediate treatment can reverse some of the effects. Within the first few days of birth, a treatment called hypothermic cooling may reverse some of the brain damage.

In cases when the brain damage is more severe and obvious after birth, treatments such as surgery, relieving pressure on the brain, draining blood from the brain, or using medications to treat seizures may be necessary.

It is more likely, however, that brain damage will not be severe or obvious and will not be noticed until the baby grows and develops. Targeted strategies can help the child overcome delays and impairment in these cases.

These include speech and language therapy, behavioral therapy, physical therapy, and educational interventions. Most importantly, knowing the causes of infant brain damage can prevent it so that no treatment is necessary.

What to Do if Your Baby Was Born with Brain Damage

The prognosis for infant brain damage varies widely, depending on the severity of the injury and other factors. Many children have a good prognosis, but your child might have lasting, even severe disabilities.

If you have given birth to a baby that shows signs of brain damage, you may think that your medical caregivers failed to provide adequate care.

In this case, you can bring a lawsuit against an individual or healthcare institution to seek justice for your child. This will help you seek compensation to give your child a better future living with brain damage. Contact an experienced birth injury lawyer to help you take the next steps toward a successful settlement.

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References

  1. Hagberg, H., Edwards, A.D., and Groenendaal, F. (2016, August). Perinatal Brain Damage: The Term Infant. Neurobiol. Dis. 92(Pt A)., 102-12.
    Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915441/
  2. Cipolla, M., & Billar, J. (2017, March 28). Persistent Brain Injury after Preeclampsia. Neurology. 88(13), 1216-17.
    Retrieved from: https://n.neurology.org/content/88/13/1216
  3. Centers for Disease Control and Prevention. (2020, December 8). What are Jaundice and Kernicterus?
    Retrieved from: https://archive.cdc.gov/#/details?url=https://www.cdc.gov/ncbddd/jaundice/facts.html
View All References
Page Medically Reviewed and Edited by Pierrette Mimi Poinsett, M.D.

Page Medically Reviewed and Edited by Pierrette Mimi Poinsett, M.D.

Dr. Poinsett is a board certified pediatrician. She is a graduate of The University of Chicago, Pritzker School of Medicine, and has over 20 years of clinical experience. She has extensive experience in the case management of children with special mental health and physical health care needs, including developmental disabilities.

See Full Bio

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